Putting DNA to Work
The Meaning Of Genetic Variation
 Overview of Activity
Students investigate variations in the beta globin gene by comparing DNA sequences
from a normal individual and a person who has sickle cell disease. They observe
the mutation that leads to the disease. Through a case study, students explore
all aspects of sickle cell disease from transmission to symptoms to detection.
Activity Type: Online or In Class
URL: http://science-education.nih.gov/supplements/nih1/genetic/activities/activity2.htm
Level of Difficulty: Intermediate
or Advanced
Amount of Time Required for Activity:
Two to three 45 minute periods
Description
This activity is designed to help students explore human genetic variation
through the process of active, collaborative learning. It is part of a larger
module that includes four related activites and a teacher's guide. One of
the related activities, Alike But Not the Same,
is a suggested pre-visit activity.
The activity is completely downloadable in PDF format
as a lesson plan. The activities include explicit instructions
in terms of preparation time, organization, and teaching
techniques. Activity sheets for students are provided.
The Meaning of Genetic Variation makes use of the Human
Genetic Variation website. If computers are not
available, the activity can be done in the classroom
using downloadable PDF files.
This activity is produced by the National Institutes
of Health.
Relation to the Science Standards
Content Standard A - Understanding about Scientific Inquiry
Content Standard C - Life Science - The Cell and Molecular Basis of Heredity
Content Standard F - Science in Personal and Social Perspectives--Personal
and Community Health, Population Control
Content Standard G - Science as a Human Endeavor and Nature of Scientific Knowledge
Relation to the Exhibit
Introduction
Inherited Disease
PDFs Related to the Activity
http://science-education.nih.gov/supplements/nih1/genetic/guide/pdfs/ACT2.PDF
http://science-education.nih.gov/supplements/nih1/genetic/guide/pdfs/ACT2M.PDF
http://science-education.nih.gov/supplements/nih1/genetic/guide/pdfs/ACT2NOCD.pdf
Related Resources
Tracing Ancestry - In Depth Report - NewsHour
 More
Post-Visit Activities
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